Multiomics Analysis Reveals the Prognostic Non-tumor Cell Landscape in Glioblastoma Niches.

ABSTRACT: A comprehensive characterization of non-tumor cells in the niches of primary glioblastoma is not fully established yet. This study aims to present an overview of non-malignant cells in the complex microenvironment of glioblastoma with detailed characterizations of their prognostic effects. We curate 540 gene signatures covering a total of 64 non-tumor cell types. Cell type-specific expression patterns are interrogated by normalized enrichment score across four large gene expression profiling cohorts of glioblastoma with a total number of 967 cases. The glioblastoma multiforms (GBMs) in each cohort are hierarchically clustered into negative or positive immune response classes with significantly different overall survival. Our results show that astrocytes, macrophages, monocytes, NKTs, and M

SUBMITTER: Xiao Z 

PROVIDER: S-EPMC8481948 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature