Ontology highlight
ABSTRACT:
SUBMITTER: Vo DT
PROVIDER: S-EPMC8481972 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Vo Daniella T DT Fuller MacKenzie R MR Tindle Courtney C Anandachar Mahitha Shree MS Das Soumita S Sahoo Debashis D Ghosh Pradipta P
iScience 20210911 10
Transient depletion of the transcription elongation factor SPT6 in the keratinocyte has been recently shown to inhibit epidermal differentiation and stratification; instead, they transdifferentiate into a gut-like lineage. We show here that this phenomenon of transdifferentiation recapitulates Barrett's metaplasia, the only human pathophysiologic condition in which a stratified squamous epithelium that is injured due to chronic acid reflux is trans-committed into an intestinal fate. The evidence ...[more]