Data for molecular dynamics simulations of <i>Escherichia coli</i> cytochrome <i>bd</i> oxidase with the Amber force field.

ABSTRACT: Cytochrome bd-type quinol oxidase is an important metalloenzyme that allows many bacteria to survive in low oxygen conditions. Since bd oxidase is found in many prokaryotes but not in eukaryotes, it has emerged as a promising bacterial drug target. Examples of organisms containing bd oxidases include the Mycobacterium tuberculosis (Mtb) bacterium that causes tuberculosis (TB) in humans, the Vibrio cholerae bacterium that causes cholera, the Pseudomonas aeruginosa bacterium that contributes to antibiotic resistance and sepsis, and the Campylobacter jejuni bacterium that causes food poisoning. Escherichia coli (E. coli) is another organism exhibiting the cytochrome bd oxidase. Since it has the highest sequence identity to Mtb<

SUBMITTER: Ahn SH 

PROVIDER: S-EPMC8481974 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature