Stimuli-Responsive Nucleotide-Amino Acid Hybrid Supramolecular Hydrogels.

ABSTRACT: The ability to assemble chemically different gelator molecules into complex supramolecular hydrogels provides excellent opportunities to construct functional soft materials. Herein, we demonstrate the formation of hybrid nucleotide-amino acid supramolecular hydrogels. These are generated by the silver ion (Ag+)-triggered formation of silver-guanosine monophosphate (GMP) dimers, which undergo self-assembly through non-covalent interactions to produce nanofilaments. This process results in a concomitant pH reduction due to the abstraction of a proton from the guanine residue, which triggers the in situ gelation of a pH-sensitive amino acid, N-fluorenylmethyloxycarbonyl tyrosine (FY), to form nucleotide-amino acid hybrid hydrogels. Alterations in the supramolecular structures due to changes i

SUBMITTER: Mulvee M 

PROVIDER: S-EPMC8482081 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature