17β-Estradiol Regulates miR-9-5p and miR-9-3p Stability and Function in the Aged Female Rat Brain.

ABSTRACT: Clinical studies demonstrated that the ovarian hormone 17β-estradiol (E₂) is neuroprotective within a narrow window of time following menopause, suggesting that there is a biological switch in E₂ action that is temporally dependent. However, the molecular mechanisms mediating this temporal switch have not been determined. Our previous studies focused on microRNAs (miRNA) as one potential molecular mediator and showed that E₂ differentially regulated a subset of mature miRNAs which was dependent on age and the length of time following E₂ deprivation. Notably, E₂ significantly increased both strands of the miR-9 duplex (miR-9-5p and miR-9-3p) in the hypothalamus, raising the possibility that E₂ could regulate miRNA stability/d

SUBMITTER: Kim CK 

PROVIDER: S-EPMC8482090 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature