Analysis of Using the Total White Blood Cell Count to Define Severe New-onset Ulcerative Colitis in Children.

ABSTRACT:

Objectives

The aim of this study was to assess common laboratory tests in identifying severe ulcerative colitis in children at diagnosis.

Methods

A cohort of 427 children 4 to 17 years of age newly diagnosed with ulcerative colitis (UC) was prospectively enrolled. Boosted classification trees were used to characterize predictive ability of disease attributes based on clinical disease severity using Pediatric Ulcerative Colitis Activity Index (PUCAI), severe (65+) versus not severe (<65) and total Mayo score, severe (10-12) versus not severe (<10); mucosal disease by Mayo endoscopic subscore, severe (3) versus not severe (<3); and extensive disease versus not extensive (left-sided and proctosigmoiditis).

Results

Mean age was 12.7 years; 49.6% (n = 212) were girls, and

SUBMITTER: Mack DR 

PROVIDER: S-EPMC8482284 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature