The Genetic Architecture of Depression in Individuals of East Asian Ancestry: A Genome-Wide Association Study.

ABSTRACT:

Importance

Most previous genome-wide association studies (GWAS) of depression have used data from individuals of European descent. This limits the understanding of the underlying biology of depression and raises questions about the transferability of findings between populations.

Objective

To investigate the genetics of depression among individuals of East Asian and European descent living in different geographic locations, and with different outcome definitions for depression.

Design, setting, and participants

Genome-wide association analyses followed by meta-analysis, which included data from 9 cohort and case-control data sets comprising individuals with depression and control individuals of East Asian descent. This study was conducted between January 2019 and May

SUBMITTER: Giannakopoulou O 

PROVIDER: S-EPMC8482304 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature