CAL-1 as Cellular Model System to Study CCR7-Guided Human Dendritic Cell Migration.

ABSTRACT: Dendritic cells (DCs) are potent and versatile professional antigen-presenting cells and central for the induction of adaptive immunity. The ability to migrate and transport peripherally acquired antigens to draining lymph nodes for subsequent cognate T cell priming is a key feature of DCs. Consequently, DC-based immunotherapies are used to elicit tumor-antigen specific T cell responses in cancer patients. Understanding chemokine-guided DC migration is critical to explore DCs as cellular vaccines for immunotherapeutic approaches. Currently, research is hampered by the lack of appropriate human cellular model systems to effectively study spatio-temporal signaling and CCR7-driven migration of human DCs. Here, we report that the previously established human neoplastic cell line CAL-1 expresse

SUBMITTER: Uetz-von Allmen E 

PROVIDER: S-EPMC8482423 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature