Histological regression of gastrointestinal peritoneal metastases after systemic chemotherapy.

ABSTRACT:

Objectives

Peritoneal metastases (PM) are relatively resistant to systemic chemotherapy, and data on histological response to therapy is rare. The aim of this study was to quantify the treatment response of PM after systemic chemotherapy.

Methods

Retrospective monocentric cohort study of 47 consecutive patients with PM from gastrointestinal origin undergoing surgery (cytoreduction: CRS + Hyperthermic IntraPEritoneal Chemotherapy [HIPEC] or Pressurized IntraPeritoneal Aerosol Chemotherapy [PIPAC]) after prior systemic chemotherapy from 1.2015 to 3.2019. Tumor response was assessed using the 4-scale Peritoneal Regression Grading System (PRGS) (4: vital tumor to 1: complete response).

Results

Patients had a median of 2 (range: 1-7) lines and 10 (3-39) cycles of prior sys

SUBMITTER: Toussaint L 

PROVIDER: S-EPMC8482450 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature