Rational Design of Hit Compounds Targeting Staphylococcus aureus Threonyl-tRNA Synthetase.

ABSTRACT: Staphylococcus aureus is one of the most dangerous nosocomial pathogens which cause a wide variety of hospital-acquired infectious diseases. S. aureus is considered as a superbug due to the development of multidrug resistance to all current therapeutic regimens. Therefore, the discovery of antibiotics with novel mechanisms of action to combat staphylococcal infections is of high priority for modern medicinal chemistry. Nowadays, aminoacyl-tRNA synthetases are considered as promising molecular targets for antibiotic development. In the present study, we used for the first time S. aureus threonyl-tRNA synthetase (ThrRS) as a molecular target. Recombinant S. aureus ThrRS was obtained in the soluble form in a sufficient amount for inhibitor screening assay. Using th

SUBMITTER: Rybak MY 

PROVIDER: S-EPMC8482496 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature