Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study.

ABSTRACT:

Background

Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in an increased burden of cardiovascular disease in breast cancer survivors. Risk stratification may help address this clinical dilemma. This study is the first to assess the association between a coronary artery disease-specific polygenic risk score and incident coronary artery events in female breast cancer survivors.

Methods

We utilized the Studies in Epidemiology and Research in Cancer Heredity prospective cohort involving 12,413 women with breast cancer with genotype information and without a baseline history of cardiovascul

SUBMITTER: Liou L 

PROVIDER: S-EPMC8482562 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature