Stemness-related LncRNA pair signature for predicting therapy response in gastric cancer.

ABSTRACT:

Objective

As a critical feature of cancers, stemness is acknowledged as a contributor to the development of drug resistance in gastric cancer (GC). LncRNAs have been revealed to participate in this process. In this study, we tried to develop a stemness-related lncRNA pair signature as guidance for clinical decisions.

Methods

The analysis was initiated by collecting stemness-related lncRNAs in TCGA cohort. The differentially expressed stemness-related lncRNAs between normal and tumor tissues in GC patients from TCGA datasets were further collected to establish the signature based on Lasso and Cox regression analyses. The predictive efficacy of the signature for chemotherapy and immunotherapy was also tested. The practicality of this signature was also validated by Zhongshan c

SUBMITTER: Jiang Q 

PROVIDER: S-EPMC8482617 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature