Synergistic effects of silver ions and metformin against enterococcus faecalis under high-glucose conditions in vitro.

ABSTRACT:

Background

This study aimed to evaluate the synergistic antibacterial activities of silver ions (Ag⁺) and metformin hydrochloride (Met) against Enterococcus faecalis (E. faecalis) under normal or high-glucose conditions.

Results

The minimum inhibitory concentration, minimum bactericidal concentration, growth curves, and colony-forming units were used to evaluate the antibacterial effects of Ag⁺ and Met on planktonic E. faecalis in Brain Heart Infusion broth with or without additional glucose. The influences of Ag⁺ and Met on four weeks E. faecalis biofilm on human dentin slices was also tested. Cytotoxicity was tested on MC3T3-E1 osteoblastic cells using CCK-8 assays. The results indicated that E. faecalis showed higher resistance to drug tre

SUBMITTER: Wu X 

PROVIDER: S-EPMC8482635 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature