MMP1 and MMP9 are potential prognostic biomarkers and targets for uveal melanoma.

ABSTRACT:

Background

Uveal melanoma (UVM) is the leading cause of eye-related mortality worldwide. This study aimed to explore the expression and prognostic value of matrix metalloproteinases (MMPs) in UVM.

Methods

Gene expression levels were obtained from the Gene Expression Omnibus (GEO) and Oncomine databases. Functional and pathway enrichment analyses were performed using the Metascape database. GeneMANIA was then applied to construct a protein-protein interaction network and identify the hub genes. Moreover, overall survival (OS) and disease-free survival (DFS) analysis for the hub genes was performed using the UALCAN and Gene Expression Profiling Interactive Analysis (GEPIA) online tool. Furthermore, TRRUST was used to predict the targets of the MMPs.

Results

Our results

SUBMITTER: Wang T 

PROVIDER: S-EPMC8482640 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature