METTL3-dependent RNA m⁶A dysregulation contributes to neurodegeneration in Alzheimer's disease through aberrant cell cycle events.

ABSTRACT:

Background

N6-methyladenosine (m⁶A) modification of RNA influences fundamental aspects of RNA metabolism and m⁶A dysregulation is implicated in various human diseases. In this study, we explored the potential role of RNA m⁶A modification in the pathogenesis of Alzheimer disease (AD).

Methods

We investigated the m⁶A modification and the expression of m⁶A regulators in the brain tissues of AD patients and determined the impact and underlying mechanism of manipulated expression of m⁶A levels on AD-related deficits both in vitro and in vivo.

Results

We found decreased neuronal m⁶A levels along with significantly reduced expression of m⁶A methyltransferase like 3 (METTL3) in AD brains.

SUBMITTER: Zhao F 

PROVIDER: S-EPMC8482683 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature