DNA Methylation Based Molecular Subtypes Predict Prognosis in Breast Cancer Patients.

ABSTRACT:

Background

Epigenetic changes are tightly linked to tumorigenesis development and malignant transformation' However, DNA methylation occurs earlier and is constant during tumorigenesis. It plays an important role in controlling gene expression in cancer cells.

Methods

In this study, we determining the prognostic value of molecular subtypes based on DNA methylation status in breast cancer samples obtained from The Cancer Genome Atlas database (TCGA).

Results

Seven clusters and 204 corresponding promoter genes were identified based on consensus clustering using 166 CpG sites that significantly influenced survival outcomes. The overall survival (OS) analysis showed a significant prognostic difference among the 7 groups (p<0.05). Finally, a prognostic model was used to es

SUBMITTER: Wu ZH 

PROVIDER: S-EPMC8482718 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature