Mitonuclear Interactions Produce Diverging Responses to Mild Stress in Drosophila Larvae.

ABSTRACT: Mitochondrial function depends on direct interactions between respiratory proteins encoded by genes in two genomes, mitochondrial and nuclear, which evolve in very different ways. Serious incompatibilities between these genomes can have severe effects on development, fitness and viability. The effect of subtle mitonuclear mismatches has received less attention, especially when subject to mild physiological stress. Here, we investigate how two distinct physiological stresses, metabolic stress (high-protein diet) and redox stress [the glutathione precursor N-acetyl cysteine (NAC)], affect development time, egg-to-adult viability, and the mitochondrial physiology of Drosophila larvae with an isogenic nuclear background set against three mitochondrial DNA (mtDNA) haplotypes: one coevolv

SUBMITTER: Rodriguez E 

PROVIDER: S-EPMC8482813 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature