Taxonomic and Functional Dysregulation in Salivary Microbiomes During Oral Carcinogenesis.

ABSTRACT: Exploring microbial community compositions in humans with healthy versus diseased states is crucial to understand the microbe-host interplay associated with the disease progression. Although the relationship between oral cancer and microbiome was previously established, it remained controversial, and yet the ecological characteristics and their responses to oral carcinogenesis have not been well studied. Here, using the bacterial 16S rRNA gene amplicon sequencing along with the in silico function analysis by PICRUSt2 (Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2), we systematically characterized the compositions and the ecological drivers of saliva microbiome in the cohorts of orally healthy, non-recurrent oral verrucous hyperplasia (a pre-cance

SUBMITTER: Chen JW 

PROVIDER: S-EPMC8482814 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature