Associations of Toll-like Receptor Gene Polymorphisms with NETosis Activity as Prognostic Criteria for the Severity of Pneumonia.

ABSTRACT: The aim of the study was to determine the molecular genetic prognostic criteria for the severity of the course pneumonia based on the analysis of the association of genetic polymorphism in toll-like receptors with the severity of NETosis.

Materials and methods

The study included 38 patients with the main diagnosis of community-acquired pneumonia with a severe course. All the patients underwent standard clinical laboratory examinations, computed tomography of the thoracic organs, microbiological examination of blood and tracheobronchial aspirate. The level of neutrophilic extracellular traps (NETs) in blood smears was determined on the 1^st-2^nd and 5^th-7^th days of hospitalization. Genotyping of rs5743551 (TLR1), rs5743708 (T

SUBMITTER: Karnaushkina MA 

PROVIDER: S-EPMC8482823 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature