Pervasive Positive Selection on Virus Receptors Driven by Host-Virus Conflicts in Mammals.

ABSTRACT: Viruses hijack cellular proteins, known as viral receptors, to initiate their infections. Viral receptors are subject to two conflicting directional forces, namely, negative selection to maintain their cellular function and positive selection resulted from the ever-changing host-virus arms race. Much remains unclear about how viral receptors evolved in mammals and whether viral receptors from different mammal groups experienced different strengths of natural selection. Here, we perform evolutionary analyses of 92 viral receptors in five major orders of mammals, including Carnivora, Cetartiodactyla, Chiroptera, Primates, and Rodentia. In all five mammal orders, signals of positive selection are detected for a high proportion of viral receptors (from 41% in Carnivora to 65% in Rodentia). Man

SUBMITTER: Wang W 

PROVIDER: S-EPMC8482839 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature