A Multimodal Risk Network Predicts Executive Function Trajectories in Non-demented Aging.

ABSTRACT: Background: Multiple modalities of Alzheimer's disease (AD) risk factors may operate through interacting networks to predict differential cognitive trajectories in asymptomatic aging. We test such a network in a series of three analytic steps. First, we test independent associations between three risk scores (functional-health, lifestyle-reserve, and a combined multimodal risk score) and cognitive [executive function (EF)] trajectories. Second, we test whether all three associations are moderated by the most penetrant AD genetic risk [Apolipoprotein E (APOE) ε4+ allele]. Third, we test whether a non-APOE AD genetic risk score further moderates these APOE × multimodal risk score associations. Methods: We assembled a longitudinal data set (spanning a

SUBMITTER: Sapkota S 

PROVIDER: S-EPMC8482841 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature