Postmitotic Prox1 Expression Controls the Final Specification of Cortical VIP Interneuron Subtypes.

ABSTRACT: Throughout development, neuronal identity is controlled by key transcription factors that determine the unique properties of a cell. During embryogenesis, the transcription factor Prox1 regulates VIP-positive cortical interneuron migration, survival, and connectivity. Here, we explore the role of Prox1 as a regulator of genetic programs that guide the final specification of VIP interneuron subtypes in early postnatal life. Synaptic in vitro electrophysiology in male and female mice shows that postnatal Prox1 removal differentially affects the dynamics of excitatory inputs onto VIP bipolar and multipolar subtypes. RNA sequencing reveals that one of the downstream targets of Prox1 is the postsynaptic protein Elfn1, a constitutive regulator of presynaptic release probability. Further g

SUBMITTER: Stachniak TJ 

PROVIDER: S-EPMC8482865 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature