Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India.
Ontology highlight
ABSTRACT: Purpose
This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.Methods
One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.Results
Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented with leukocoria. Molecular investigation by different methods revealed no HPV positivity in any tumor genome.Conclusion
Our study demonstrates no association between HPV and RB, postulating HPV may not be a major risk factor in the etiology of RB.
SUBMITTER: Jeyaprakash K
PROVIDER: S-EPMC8482879 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Human papillomavirus in retinoblastoma: A tertiary eye care center study from South India.
Jeyaprakash Kumar K Shanthini Thennarasu T Kim Usha U Muthukkaruppan Veerappan V Vanniarajan Ayyasamy A
Indian journal of ophthalmology 20210801 8
<h4>Purpose</h4>This study is aimed to investigate the presence of Human papillomavirus (HPV) DNA in tumors obtained from sporadic retinoblastoma patients.<h4>Methods</h4>One hundred six tumor tissues obtained from sporadic RB patients were analyzed for HPV infection by use of both seminested PCR and real-time quantitative PCR.<h4>Results</h4>Of 106 RB patients, 55 were male and 51 were female. The mean age at diagnosis was 26.77 ± 15.36 (mean ± Std. dev) months. Almost all patients presented wi ...[more]
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