Abnormal right ventricular-pulmonary artery coupling with exercise in heart failure with preserved ejection fraction.

ABSTRACT:

Background

Exercise intolerance is common in people with heart failure and preserved ejection fraction (HFpEF). Right ventricular (RV) dysfunction has been shown at rest in HFpEF but little data are available regarding dynamic RV-pulmonary artery (PA) coupling during exercise.

Methods and results

Subjects with HFpEF (n = 50) and controls (n = 24) prospectively underwent invasive cardiopulmonary exercise testing using high-fidelity micromanometer catheters along with simultaneous assessment of RV and left ventricular (LV) mechanics by echocardiography. Compared with controls at rest, subjects with HFpEF displayed preserved RV systolic and diastolic mechanics (RV s' and e'), impaired LV s' and e', higher biventricular filling pressures, and higher pulmonary artery pressures. O

SUBMITTER: Borlaug BA 

PROVIDER: S-EPMC8483148 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature