Antigen-Specific T-Cell Activation Distinguishes between Recent and Remote Tuberculosis Infection.

ABSTRACT: Rationale: Current diagnostic tests fail to identify individuals at higher risk of progression to tuberculosis disease, such as those with recent Mycobacterium tuberculosis infection, who should be prioritized for targeted preventive treatment. Objectives: To define a blood-based biomarker, measured with a simple flow cytometry assay, that can stratify different stages of tuberculosis infection to infer risk of disease. Methods: South African adolescents were serially tested with QuantiFERON-TB Gold to define recent (QuantiFERON-TB conversion <6 mo) and persistent (QuantiFERON-TB+ for >1 yr) infection. We defined the ΔHLA-DR median fluorescence intensity biomarker as the difference in HLA-DR expression between IFN-γ⁺ TNF⁺ Mycobacterium t

SUBMITTER: Mpande CAM 

PROVIDER: S-EPMC8483229 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature