Cortical responsive neurostimulation in a baboon with genetic generalized epilepsy.

ABSTRACT:

Objective

To evaluate the efficacy of cortical responsive neurostimulation (CRN) in a male baboon with epilepsy and with genetic generalized epilepsy (GGE), as well as the alteration of seizure patterns and their circadian rhythms due to treatment.

Methods

The baboon was implanted with two subdural frontoparietal strips, bridging the medial central sulci bilaterally. Electrocorticography (ECoG) data were downloaded daily during a three-month baseline, then every 2-3 days over a five-month treatment period. Long episodes, reflecting ictal or interictal epileptic discharges, were also quantified.

Results

Twenty-three generalized tonic-clonic seizures (GTCS) and 2 episodes of nonconvulsive status epilepticus (NCSE) were recorded at baseline (median 8 events/month), where

SUBMITTER: Akos Szabo C 

PROVIDER: S-EPMC8483259 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature