Integrating additional factors into the TNM staging for cutaneous melanoma by machine learning.

ABSTRACT:

Background

Integrating additional factors into the TNM staging system is needed for more accurate risk classification and survival prediction for patients with cutaneous melanoma. In the present study, we introduce machine learning as a novel tool that incorporates additional prognostic factors to improve the current TNM staging system.

Methods and findings

Cancer-specific survival data for cutaneous melanoma with at least a 5 years follow-up were extracted from the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute and split into the training set (40,781 cases) and validation set (5,390 cases). Five factors were studied: the primary tumor (T), regional lymph nodes (N), distant metastasis (M), age (A), and sex (S). The Ensemble Algorithm for

SUBMITTER: Yang CQ 

PROVIDER: S-EPMC8483349 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature