Burden of invasive group B Streptococcus disease in non-pregnant adults: A systematic review and meta-analysis.

ABSTRACT:

Background

Streptococcus agalactiae or group B Streptococcus (GBS) has emerged as an important cause of invasive disease in adults, particularly among the elderly and those with underlying comorbidities. Traditionally, it was recognised as an opportunistic pathogen colonising and causing disease in pregnant women, neonates, and young infants. Reasons for the upsurge of invasive GBS (iGBS) among the elderly remain unclear, although it has been related to risk factors such as underlying chronic diseases, immunosenescence, impaired inflammatory response, and spread of virulent clones. Antibiotics are successfully as treatment or prophylaxis against iGBS. Several candidate vaccines against iGBS are under development.

Objectives

To conduct a systematic review of the current liter

SUBMITTER: Navarro-Torne A 

PROVIDER: S-EPMC8483371 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature