Differences in olfactory bulb mitral cell spiking with ortho- and retronasal stimulation revealed by data-driven models.

ABSTRACT: The majority of olfaction studies focus on orthonasal stimulation where odors enter via the front nasal cavity, while retronasal olfaction, where odors enter the rear of the nasal cavity during feeding, is understudied. The coding of retronasal odors via coordinated spiking of neurons in the olfactory bulb (OB) is largely unknown despite evidence that higher level processing is different than orthonasal. To this end, we use multi-electrode array in vivo recordings of rat OB mitral cells (MC) in response to a food odor with both modes of stimulation, and find significant differences in evoked firing rates and spike count covariances (i.e., noise correlations). Differences in spiking activity often have implications for sensory coding, thus we develop a single-compartment biophysical OB mode

SUBMITTER: Craft MF 

PROVIDER: S-EPMC8483419 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature