Ontology highlight
ABSTRACT:
SUBMITTER: Atmar RL
PROVIDER: S-EPMC8483565 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Atmar Robert L RL Cramer Jakob P JP Baehner Frank F Han Cong C Borkowski Astrid A Mendelman Paul M PM
The Journal of infectious diseases 20190101 3
As noroviruses are transmitted through the fecal-oral route, we investigated humoral and mucosal (salivary immunoglobulin A [IgA]) immune responses in a phase 2 trial of Takeda's bivalent norovirus virus-like particle (VLP) vaccine candidate in 50 healthy 18- to 49-year-olds. The vaccine had an acceptable tolerability profile and induced rapid, robust humoral immune responses after 1 intramuscular dose of vaccine candidate. Seroresponses were evident 8 days after vaccination as panimmunoglobulin ...[more]