Phosphodiesterase 4 mediates interleukin-8-induced heterologous desensitization of the β₂ -adrenergic receptor.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is a life-threatening illness characterized by decreased alveolar-capillary barrier function, pulmonary edema consisting of proteinaceous fluid, and inhibition of net alveolar fluid transport responsible for resolution of pulmonary edema. There is currently no pharmacotherapy that has proven useful to prevent or treat ARDS, and two trials using beta-agonist therapy to treat ARDS demonstrated no effect. Prior studies indicated that IL-8-induced heterologous desensitization of the beta2-adrenergic receptor (β₂ -AR) led to decreased beta-agonist-induced mobilization of cyclic adenosine monophosphate (cAMP). Interestingly, phosphodiesterase (PDE) 4 inhibitors have been used in human airway diseases characterized by low intracellular cAMP le

SUBMITTER: Rich TC 

PROVIDER: S-EPMC8483573 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature