Development of Nanosilicate-Hydrogel Composites for Sustained Delivery of Charged Biopharmaceutics.

ABSTRACT: Nanocomposite hydrogels containing two-dimensional nanosilicates (NS) have emerged as a new technology for the prolonged delivery of biopharmaceuticals. However, little is known about the physical-chemical properties governing the interaction between NS and proteins and the release profiles of NS-protein complexes in comparison to traditional poly(ethylene glycol) (PEG) hydrogel technologies. To fill this gap in knowledge, we fabricated a nanocomposite hydrogel composed of PEG and laponite and identified simple but effective experimental conditions to obtain sustained protein release, up to 23 times slower as compared to traditional PEG hydrogels, as determined by bulk release experiments and fluorescence correlation spectroscopy. Slowed protein release was attributed to the formation of N

SUBMITTER: Stealey ST 

PROVIDER: S-EPMC8483607 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature