Cerebral Hemodynamics and Executive Function in Sickle Cell Anemia.

ABSTRACT:

Background and purpose

Individuals with sickle cell anemia experience cognitive deficits, even in the absence of cerebral infarcts or strokes. This study tested the hypothesis that elevated cerebral blood flow and oxygen extraction fraction are associated with lower executive function in individuals with sickle cell anemia.

Methods

Three-Tesla brain magnetic resonance imaging was performed, including anatomic, gray matter cerebral blood flow, and global oxygen extraction fraction imaging. Executive function was measured using the working memory index from an age-appropriate Wechsler battery and tasks from the National Institutes of Health Toolbox Cognition Battery. Bivariate and multivariate models were examined (significance: P<0.05).

Results

Fifty-four partic

SUBMITTER: Prussien KV 

PROVIDER: S-EPMC8483619 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature