Diminished antiproteinuric effect of the angiotensin receptor blocker losartan during high potassium intake in patients with CKD.

ABSTRACT:

Background

Angiotensin II type 1 receptor blockers (ARBs) lower blood pressure (BP) and proteinuria and reduce renal disease progression in many-but not all-patients. Reduction of dietary sodium intake improves these effects of ARBs. Dietary potassium intake affects BP and proteinuria. We set out to address the effect of potassium intake on BP and proteinuria response to losartan in non-diabetic proteinuric chronic kidney disease (CKD) patients.

Methods

We performed a post hoc analysis of a placebo-controlled interventional cross-over study in 33 non-diabetic proteinuric patients (baseline mean arterial pressure and proteinuria: 105 mmHg and 3.8 g/day, respectively). Patients were treated for 6 weeks with placebo, losartan and losartan/hydrochlorothiazide (HCT), combi

SUBMITTER: Wouda RD 

PROVIDER: S-EPMC8483678 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature