Effect of Huanglian Decoction on the Intestinal Microbiome in Stress Ulcer (SU) Mice.

ABSTRACT:

Background

Stress ulcer (SU) is a serious gastrointestinal mucosal lesion under acute stress. Huanglian decoction is a famous traditional Chinese medicine prescription, which has been used to treat digestive system diseases for thousands of years. Many clinical cases have proved that Huanglian decoction has a good effect on SU. Some studies have shown that the intestinal bacteria will be changed accordingly when the gastrointestinal mucosa is damaged. However, there are few published reports on the effect of the intestinal microbiome with SU mice that were treated by Huanglian decoction. In this study, we investigated the effect of the fecal microbiome in mice with SU by the 16S rDNA sequencing technology.

Methods

Male KM mice were induced by cold-restraint stress except for

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC8483906 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature