The Effect of Renalase rs2576178 and rs10887800 Polymorphisms on Ischemic Stroke Susceptibility in Young Patients (<50 Years): A Case-Control Study and In Silico Analysis.

ABSTRACT:

Background

Ischemic stroke (IS) is the most common form of cerebrovascular accident which its precise etiology remains mysterious. Renalase is a catecholamine-degrading enzyme playing a major role in blood pressure control. Recent studies show the effect of renalase activity on various diseases like IS. In the current study, we examined the possible effects of renalase gene (RNLS) rs2576178 and rs10887800 variants at the 5'-flanking and intron 6 regions on IS, respectively.

Methods

One hundred and fifty-four IS patients younger than 50 years and 165 age- and sex-matched controls were recruited in the study. For genotyping of rs2576178 and rs10887800 variants, the PCR-RFLP method was used.

Results

The RNLS rs10887800 AG genotype was more repeated in IS pa

SUBMITTER: Ramroodi N 

PROVIDER: S-EPMC8483926 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature