Nutritional Status Impacts Epigenetic Regulation in Early Embryo Development: A Scoping Review.

ABSTRACT: With the increasing maternal age and the use of assisted reproductive technology in various countries worldwide, the influence of epigenetic modification on embryonic development is increasingly notable and prominent. Epigenetic modification disorders caused by various nutritional imbalance would cause embryonic development abnormalities and even have an indelible impact on health in adulthood. In this scoping review, we summarize the main epigenetic modifications in mammals and the synergies among different epigenetic modifications, especially DNA methylation, histone acetylation, and histone methylation. We performed an in-depth analysis of the regulation of various epigenetic modifications on mammals from zygote formation to cleavage stage and blastocyst stage, and reviewed the modifica

SUBMITTER: Cai S 

PROVIDER: S-EPMC8483970 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature