¹H^N, ¹³C, and ¹⁵N backbone resonance assignments of the SET/TAF-1β/I2PP2A oncoprotein (residues 23-225).

ABSTRACT: SET (TAF-1β/I2PP2A) is a ubiquitously expressed, multifunctional protein that plays a role in regulating diverse cellular processes, including cell cycle progression, migration, apoptosis, transcription, and DNA repair. SET expression is ubiquitous across all cell types. However, it is overexpressed or post-translationally modified in several solid tumors and blood cancers, where expression levels are correlated with worsening clinical outcomes. SET exerts its oncogenic effects primarily through the formation of antagonistic protein complexes with the tumor suppressor, protein phosphatase 2A (PP2A), and the well-known metastasis suppressor, nm23-H1. PP2A inhibition is often observed as a secondary driver of tumorigenesis and metastasis in human cancers. Preclinical studies have shown that

SUBMITTER: Roth BM 

PROVIDER: S-EPMC8484053 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature