⁶⁸Ga-FAPI-PET/CT in patients with various gynecological malignancies.

ABSTRACT:

Purpose

⁶⁸Ga-FAPI (fibroblast activation protein inhibitor) is a novel and highly promising radiotracer for PET/CT imaging. The aim of this retrospective analysis is to explore the potential of FAPI-PET/CT in gynecological malignancies. We assessed biodistribution, tumor uptake, and the influence of pre- or postmenopausal status on tracer accumulation in hormone-sensitive organs. Furthermore, a comparison with the current standard oncological tracer ¹⁸F-FDG was performed in selected cases.

Patients and methods

A total of 31 patients (median age 59.5) from two centers with several gynecological tumors (breast cancer; ovarian cancer; cervical cancer; endometrial cancer; leiomyosarcoma of the uterus; tubal cancer) underwent ⁶⁸Ga-FAPI-PET/CT. Out

SUBMITTER: Dendl K 

PROVIDER: S-EPMC8484099 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature