Feasibility of short imaging protocols for [¹⁸F]PI-2620 tau-PET in progressive supranuclear palsy.

ABSTRACT:

Purpose

Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [¹⁸F]PI-2620 facilitated accurate discrimination between patients with progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition and static time windows can be used for [¹⁸F]PI-2620 tau-PET imaging of PSP.

Methods

Thirty-seven patients with PSP Richardson syndrome (PSP-RS) were evaluated together with ten HCs. [¹⁸F]PI-2620 PET was performed by a dynamic 60-min scan. Distribution volume ratios (DVRs) were calculated using full and truncated scan durations (0-60, 0-50, 0-40, 0-30, and 0-20 min p.i.). Standardized uptake value ratios (SUVrs) were obtained 20-40, 30-50, and 40-60 min p.i.. All DV

SUBMITTER: Song M 

PROVIDER: S-EPMC8484138 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature