What's behind ⁶⁸Ga-PSMA-11 uptake in primary prostate cancer PET? Investigation of histopathological parameters and immunohistochemical PSMA expression patterns.

ABSTRACT:

Purpose

Prostate-specific membrane antigen (PSMA-) PET has become a promising tool in staging and restaging of prostate carcinoma (PCa). However, specific primary tumour features might impact accuracy of PSMA-PET for PCa detection. We investigated histopathological parameters and immunohistochemical PSMA expression patterns on radical prostatectomy (RPE) specimens and correlated them to the corresponding ⁶⁸Ga-PSMA-11-PET examinations.

Methods

RPE specimens of 62 patients with preoperative ⁶⁸Ga-PSMA-11-PET between 2016 and 2018 were analysed. WHO/ISUP grade groups, growth pattern (expansive vs. infiltrative), tumour area and diameter as well as immunohistochemical PSMA heterogeneity, intensity and negative tumour area (PSMA_%neg) were correlate

SUBMITTER: Ruschoff JH 

PROVIDER: S-EPMC8484204 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature