The SKI proto-oncogene restrains the resident CD103⁺CD8⁺ T cell response in viral clearance.

ABSTRACT: Acute viral infection causes illness and death. In addition, an infection often results in increased susceptibility to a secondary infection, but the mechanisms behind this susceptibility are poorly understood. Since its initial identification as a marker for resident memory CD8⁺ T cells in barrier tissues, the function and regulation of CD103 integrin (encoded by ITGAE gene) have been extensively investigated. Nonetheless, the function and regulation of the resident CD103⁺CD8⁺ T cell response to acute viral infection remain unclear. Although TGFβ signaling is essential for CD103 expression, the precise molecular mechanism behind this regulation is elusive. Here, we reveal a TGFβ-SKI-Smad4 pathway that critically and specifically directs resident CD103

SUBMITTER: Wu B 

PROVIDER: S-EPMC8484360 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature