A differential DNA methylome signature of pulmonary immune cells from individuals converting to latent tuberculosis infection.

ABSTRACT: Tuberculosis (TB), caused by Mycobacterium tuberculosis, spreads via aerosols and the first encounter with the immune system is with the pulmonary-resident immune cells. The role of epigenetic regulations in the immune cells is emerging and we have previously shown that macrophages capacity to kill M. tuberculosis is reflected in the DNA methylome. The aim of this study was to investigate epigenetic modifications in alveolar macrophages and T cells in a cohort of medical students with an increased risk of TB exposure, longitudinally. DNA methylome analysis revealed that a unique DNA methylation profile was present in healthy subjects who later developed latent TB during the study. The profile was reflected in a different overall DNA methylation distribution as well as a distinct set of dif

SUBMITTER: Karlsson L 

PROVIDER: S-EPMC8484443 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature