Ontology highlight
ABSTRACT:
SUBMITTER: Ponnusamy V
PROVIDER: S-EPMC8484486 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Ponnusamy Vennila V Ip Richard T H RTH Mohamed Moumin A E K MAEK Clarke Paul P Wozniak Eva E Mein Charles C Schwendimann Leslie L Barlas Akif A Chisholm Philippa P Chakkarapani Ela E Michael-Titus Adina T AT Gressens Pierre P Yip Ping K PK Shah Divyen K DK
Communications biology 20210930 1
Despite increasing knowledge on microRNAs, their role in the pathogenesis of neonatal encephalopathy remains to be elucidated. Herein, we identify let-7b-5p as a significant microRNA in neonates with moderate to severe encephalopathy from dried blood spots using next generation sequencing. Validation studies using Reverse Transcription and quantitative Polymerase Chain Reaction on 45 neonates showed that let-7b-5p expression was increased on day 1 in neonates with moderate to severe encephalopat ...[more]