Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy.

ABSTRACT: Cancer treatment is a significant challenge for the global health system, although various pharmacological and therapeutic discoveries have been made. It has been widely established that cancer is associated with epigenetic modification, which is reversible and becomes an attractive target for drug development. Adding chemical groups to the DNA backbone and modifying histone proteins impart distinct characteristics on chromatin architecture. This process is mediated by various enzymes modifying chromatin structures to achieve the diversity of epigenetic space and the intricacy in gene expression files. After decades of effort, epigenetic modification has represented the hallmarks of different cancer types, and the enzymes involved in this process have provided novel targets for antitumor t

SUBMITTER: Xiao W 

PROVIDER: S-EPMC8484527 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature