Ontology highlight
ABSTRACT:
SUBMITTER: Ashraf B
PROVIDER: S-EPMC8484570 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Ashraf Bilal B Lawson Daniel John DJ
European journal of human genetics : EJHG 20210413 10
Most complex traits evolved in the ancestors of all modern humans and have been under negative or balancing selection to maintain the distribution of phenotypes observed today. Yet all large studies mapping genomes to complex traits occur in populations that have experienced the Out-of-Africa bottleneck. Does this bottleneck affect the way we characterise complex traits? We demonstrate using the 1000 Genomes dataset and hypothetical complex traits that genetic drift can strongly affect the joint ...[more]