Chromatin accessibility associates with protein-RNA correlation in human cancer.

ABSTRACT: Although alterations in chromatin structure are known to exist in tumors, how these alterations relate to molecular phenotypes in cancer remains to be demonstrated. Multi-omics profiling of human tumors can provide insight into how alterations in chromatin structure are propagated through the pathway of gene expression to result in malignant protein expression. We applied multi-omics profiling of chromatin accessibility, RNA abundance, and protein abundance to 36 human thyroid cancer primary tumors, metastases, and patient-match normal tissue. Through quantification of chromatin accessibility associated with active transcription units and global protein expression, we identify a local chromatin structure that is highly correlated with coordinated RNA and protein expression. In particular,

SUBMITTER: Sanghi A 

PROVIDER: S-EPMC8484618 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature