Mosaic vaccination: How distributing different vaccines across a population could improve epidemic control.

ABSTRACT: Although vaccination has been remarkably effective against some pathogens, for others, rapid antigenic evolution results in vaccination conferring only weak and/or short-lived protection. Consequently, considerable effort has been invested in developing more evolutionarily robust vaccines, either by targeting highly conserved components of the pathogen (universal vaccines) or by including multiple immunological targets within a single vaccine (multi-epitope vaccines). An unexplored third possibility is to vaccinate individuals with one of a number of qualitatively different vaccines, creating a "mosaic" of individual immunity in the population. Here we explore whether a mosaic vaccination strategy can deliver superior epidemiological outcomes to "conventional" vaccination, in which all ind

SUBMITTER: McLeod DV 

PROVIDER: S-EPMC8484727 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature