Ontology highlight
ABSTRACT:
SUBMITTER: He W
PROVIDER: S-EPMC8484912 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
He Wenyan W Zhang Ying Y Cao Zhan Z Ye Zehua Z Lu Xun X Fan Junwan J Peng Wei W Li Zhuan Z
Frontiers in cell and developmental biology 20210917
The first adult repopulating hematopoietic stem cells (HSCs) are found in the aorta-gonad-mesonephros (AGM) region, which are produced from hemogenic endothelial cells. Embryonic head is the other site for HSC development. Wild-type p53-induced phosphatase 1 (Wip1) is a type-2Cδ family serine/threonine phosphatase involved in various cellular processes such as lymphoid development and differentiation of adult HSCs. Most recently, we have shown that Wip1 modulates the pre-HSC maturation in the AG ...[more]