Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Gottingen minipigs.

ABSTRACT: Bleeding during surgical procedures is a common complication. Therefore, hemostatic agents have been developed to control bleeding, and fibrin sealants have several benefits. sFilm-FS is a novel fibrin sealant that comprises a biodegradable co-polymeric film embedded with human fibrinogen and thrombin. Herein, the safety and efficacy of sFilm-FS were compared using a liver and spleen puncture model of Göttingen minipigs with those of the standard hemostatic techniques (control animals) and EVARREST^®, a reference fibrin sealant. Hemostasis and reduced blood loss were more effectively achieved with sFilm-FS than with the standard techniques in the control animals and comparable to those achieved with EVARREST^®. No treatment-related adverse effects were observed in any o

SUBMITTER: Ramot Y 

PROVIDER: S-EPMC8484930 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature